We have known now for a long time that intramuscular fat (IMAT), adipose tissue that infiltrates and replaces our muscle tissue with age and disease, is most likely bad for you. We finally have proof that this is indeed the case. In this manuscript, currently under peer-review, we investigated whether IMAT affects muscle regeneration. Using a novel genetic mouse model that blocked the formation of IMAT, we found that preventing this fat infiltration significantly improved muscle recovery and function following injury. Specifically, muscles with reduced IMAT displayed greater myofiber density and size, sugg
esting that IMAT impedes muscle healing by acting as a physical barrier. These findings underscore the importance of targeting IMAT to enhance muscle recovery in clinical settings. This work was a great team effort with the Ryan lab led by Ale.
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